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Shames, S.R. 2023. Eat or be Eaten: Strategies used by Legionella to acquire host-derived nutrients and evade lysosomal degradation. Infection and Immunity. In press.

Chauhan, D., Joseph, A.M., Shames, S.R. 2023. Intrabacterial regulation of a cytotoxic effector by its cognate metaeffector promotes Legionella pneumophila virulence. mSphere 8:e0055222

Chauhan, D., Shames, S.R. 2021. Pathogenicity and Virulence of Legionella: Intracellular replication and host response. Virulence. 12(1):1122-1144.

Ngwaga, T., Chauhan, D., and Shames, S.R. 2021. Mechanisms of effector-mediated immunity revealed by the accidental human pathogen Legionella pneumophila.Frontiers in Cellular and Infection Microbiology. 10: 593823


Joseph, A.M. and Shames, S.R. 2021. Affecting the effectors: Regulation of Legionella pneumophila effector function by metaeffectors. Pathogens. 10: 108

Gilchrist, A.K., Smolensky, D., Ngwaga, T., Chauhan, D., Cox, S., Perumal, R., Noronha, L.E., and Shames S.R. 2020. High-polyphenol extracts from Sorghum bicolor attenuate replication of Legionella pneumophila within RAW 264.7 macrophages. FEMS Microbiology Letters. 367(7): fnaa053

Joseph, A.M., Pohl, A.E., Ball, T.J., Abram, T.G., Johnson, D.K., Geisbrecht, B.V., and Shames, S.R. 2020 The Legionella pneumophila metaeffector Lpg2505 (MesI) regulates SidI-mediated translation inhibition and novel glycosyl hydrolase activity. Infection and Immunity. 88(5): e00853-19

Ngwaga, T., Hydock, A.J., Ganesan, S., and Shames, S.R. 2019. Potentiation of cytokine-mediated restriction of Legionella intracellular replication by a Dot/Icm-translocated effector. Journal of Bacteriology. 201(14):e00755-18


Shames, S.R. 2019. Screening targeted Legionella pneumophila mutant libraries in vivo using INSeq. Methods in Molecular Biology. 1921:123-144 

Shames, S.R., Liu, L., Havey, J.C., Schofield, W.B., Goodman, A.L., and Roy, C.R. 2017. Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries. Proceedings of the National Academy of Science USA. 114:E10446-E10454

Arasaki, K., Mikami, Y., Shames, S.R., Inoue, H., Wakana, Y., Tagaya, M. 2017. Legionella Effector Lpg1137 shuts down ER-mitochondria communication through cleavage of Syntaxin 17. Nature Communications. 8:15406.

Tørring, T., Shames, S.R., Cho, W., Roy, C.R., Crawford, J.M. 2017. Acyl-histidines: New N-acyl amides from Legionella pneumophila. ChemBioChem. 18(7): 638-46.

Shames, S.R. and Finlay, B.B. 2012. Bacterial effector interplay: a new way to view effector function.  Trends in Microbiology.  20(5):214-219.

Shames, S.R., Croxen, M.A., Deng, W., and Finlay, B.B. 2011. The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17B. Infection and Immunity.79(12): 4784-4790.

Shames, S.R., Bhavsar, A.P. Croxen, M.A., Law, R.J., Mak, S.H.C., Deng, W., Bidshari, R., de Hoog, C.L., Foster, L.J., and Finlay, B.B. 2011. The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300.  Cellular Microbiology. 13(10): 1542-1557.

Sham, H.P.†, Shames, S.R.†, Croxen, M.A., Ma, C., Chan, J., Khan, M.A., Wickham, M.E., Deng, W., Finlay, B.B., and Vallance, B.A. 2011. Attaching/effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-kB and p38-MAP Kinase activation.  Infection and Immunity. 79(9): 3552-3562 † - co-first authors.

Shames, S.R., Deng, W., Guttman, J.A., de Hoog, C.L., Li, Y., Hardwidge, P.R., Sham, H.P., Vallance, B.A., Foster, L.J., and Finlay, B.B. 2010. The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signaling. Cellular Microbiology. 12(9): 1322-1339.

See the full list of Stephanie's publications at NCBI PubMed.

Ngwaga, T., Chauhan, D., Salberg, A.G., Shames, S.R. (2022) Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal targeting of Legionella pneumophila within cytokine-activated macrophages. bioRxiv.


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